The purposes of the preliminary questionnaire are:
Otherwise, we might overestimate the prevalence of epilepsy.
Sowhile most litters from one affected and one unaffected parent will haveroughly 50% affected, some litters can have zero affected and some can have100% affected.
However, it is NOT too late tobecome a participant.
Since theunaffected parent has only normal alleles for pep1, inheriting the disorderfrom this mating is like flipping a coin.
Thus,our Phase 2 packet of long instructions gets put aside.
If the mode of inheritance is complex, as we expect is true,it also will be necessary to include more distant relatives, such as aunts,uncles, cousins, great aunts, etc.
John Armstrong, University of Ottawa.
However, it is important to alsotest the possibility that at least some "subtypes" of primary epilepsy indogs are dominant, perhaps with incomplete penetrance.
For additional information on the Poodle Epilepsy Project, email
In thisexample, information on the mates of affected SPs and all their offspringwere used to help test the hypothesis that the disorder was autosomaldominant.
Help raise awareness and funds for epilepsy throughout March.
Without this information, it will not bepossible to determine whether matings of one affected and one unaffectedparent produce an average of 50% affected offspring.