Importantly, we welcome new participants who own any variety.

However, at the same time, I know that every time we identify anotherpotential participant, we get one step closer to our goal of determiningthe mode of inheritance for primary epilepsy in SPs.

The purposes of the preliminary questionnaire are:

What is important to know is that this is a long tedious, but crucial process.

Otherwise, we might overestimate the prevalence of epilepsy.

Sowhile most litters from one affected and one unaffected parent will haveroughly 50% affected, some litters can have zero affected and some can have100% affected.

However, it is NOT too late tobecome a participant.

Since theunaffected parent has only normal alleles for pep1, inheriting the disorderfrom this mating is like flipping a coin.

That is, on a general level, we have made considerable progress, but we have a long way to go.

Thus,our Phase 2 packet of long instructions gets put aside.

If the mode of inheritance is complex, as we expect is true,it also will be necessary to include more distant relatives, such as aunts,uncles, cousins, great aunts, etc.

John Armstrong, University of Ottawa.

However, it is important to alsotest the possibility that at least some "subtypes" of primary epilepsy indogs are dominant, perhaps with incomplete penetrance.

For additional information on the Poodle Epilepsy Project, email

In thisexample, information on the mates of affected SPs and all their offspringwere used to help test the hypothesis that the disorder was autosomaldominant.

Help raise awareness and funds for epilepsy throughout March.

Without this information, it will not bepossible to determine whether matings of one affected and one unaffectedparent produce an average of 50% affected offspring.

I have joked before that I am not capable of giving a short answer to any question.

This may manifest clinically (in the phenotype) asgrand mal seizures.

My choice of an autosomal dominant disorder for this example may havesurprised some of you because we usually expect disorders/diseases to berecessive rather than dominant.

However, I think it is important to explain the reasons for our procedures as well as our findings.

On average, 50% of their offspring will inherit the disorder.

During Phase 1, our goal was to collect short "preliminary" questionnairesfrom ALL owners and breeders of Poodles (all varieties), even if they neverhad problems with seizures.

Thisreport will include Standard Poodles (SPs) only because we are focusing onStandards first.

I tried to keep this example simple -- honestly!

Although we are short of our goal for Phase 2, we are pleased with theprogress we have made thus far, and we are optimistic that we eventuallywill reach our goal for Phase 2.