- Erstellung von Lehrmaterialien und -illustrationen
- Auswertung der Lehrevaluation
The human spindle and kinetochore associated (Ska) complex is required for proper mitotic progression. Extensive studies have demonstrated its important functions in both stable kinetochore‐microtubule interactions and spindle checkpoint silencing. We suggest a model to explain how various Ska functions might be fulfilled by distinct pools of Ska at kinetochores. The Ndc80‐loop pool of Ska is recruited by the Ndc80 loop, or together with some of its flanking sequences, and the recruitment is also dependent on Cdk1‐mediated Ska3 phosphorylation. This pool seems to play a more important role in silencing the spindle ch...
- Fortbildung Instituts-interner Dozenten
Conformational changes of proteins and other biomolecules play a fundamental role in their functional mechanism. Single pair Förster resonance energy transfer (spFRET) offers the possibility to detect these conformational changes and dynamics, and to characterize their underlying kinetics. Using spFRET on microscopes with different modes of detection, dynamic timescales ranging from nanoseconds to seconds can be quantified. Confocal microscopy can be used as a means to analyze dynamics in the range of nanoseconds to milliseconds, while total internal reflection fluorescence (TIRF) microscopy offers information about c...
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Different disciplines and areas of practice have often had distinct interests in fathers and children. Applied social services may be concerned with the impacts of father absence on children’s social development (including juvenile delinquency and engagement in criminal activities), on the reasons why men do or do not provide child support, or the role of father figures in child physical abuse. Other policy-oriented scholars may be interested in socially engineering more invested fathers with an eye toward enhancing child outcomes, such as increased high school graduation rates. Sociologists may be primarily concerned with socioeconomic and ethnic differences in father-child dynamics within Western countries. Evolutionary-minded scholars seek to understand the historical and adaptive bases of paternal behaviour and child development, including with respect to other animals. Anthropologists may pay more attention to the role of fathers in non-Western societies.